Skin that repairs itself.
From the inside out.
Plinest, Nucleofill and Vitaran — advanced polynucleotide treatments for deep regeneration, tissue repair and lasting rejuvenation, delivered by a GDC-registered dental professional.
Not more volume. Healthier skin.
Polynucleotides are injectable treatments made from highly purified DNA fragments. They work at a cellular level to switch on your skin’s own regeneration — increasing fibroblast activity, boosting collagen and elastin, improving hydration and accelerating the repair of damaged cells.
This is not about adding volume; it is about restoring the biological health of your skin. Mahtab offers three leading formulations — Plinest, Nucleofill and Vitaran — each with a distinct mechanism, and recommends the right one from your individual skin assessment.
Different mechanisms. One honest recommendation.
Plinest
Nucleofill
Vitaran
Plinest. Genuine cellular renewal.
Plinest uses PDRN (polydeoxyribonucleotide), a highly purified, extensively researched compound derived from salmon DNA. PDRN activates the A2A adenosine receptor pathway, directly stimulating tissue regeneration, fibroblast proliferation and the natural production of collagen and extracellular matrix.
The result is a measurable improvement in skin quality, texture and hydration that builds over a course. Plinest is particularly effective for dull, tired or photo-aged skin that needs genuine renewal rather than surface-level improvement.
Tissue regeneration
Collagen production
Deep hydration
Skin quality
Nucleofill. Intensive regeneration.
Nucleofill is a high-concentration polynucleotide gel for an intensive regenerative effect. Its higher polynucleotide density means stronger fibroblast stimulation and a more pronounced improvement in elasticity, firmness and vitality.
It is particularly suited to more advanced signs of skin ageing — loss of firmness, deep dehydration, reduced elasticity and a decline in vitality that lighter treatments haven’t fully addressed.
High concentration
Elasticity restoration
Deep revitalisation
Progressive results
Vitaran. Regeneration and hydration together.
Vitaran combines polynucleotides with hyaluronic acid in one formulation. The polynucleotides trigger the skin’s own repair and collagen-building processes, while the HA provides immediate structural hydration and plumping.
It is an excellent choice if you want the regenerative benefits of polynucleotides alongside a visible, immediate improvement — and a strong starting point if you’re new to polynucleotide treatments.
Dual action
Immediate results
Long-term repair
Versatile
A guide to the key differences.
Transparent pricing. No surprises.
Polynucleotide treatments
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Face £280
per session
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Neck £280
per session
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2 treatment package £540
-
Course of 3 £690
recommended for full results
Polynucleotide under eye
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1 session £250
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2 sessions £470
-
Course of 3 £600
Chosen once. Trusted again and again.
GDC registered
Facial anatomy expertise
Three leading formulations
Bespoke treatment plans
Calm, unhurried, entirely about you.
Free consultation
Preparation
Treatment
Aftercare
Results
Rated 4.9 on Google.
Quick answers.
Highly purified DNA fragments, derived from fish DNA, that stimulate your own cells to regenerate, produce collagen and improve hydration when injected into the skin. They are one of the most researched categories of injectable skin treatment.
A full course is typically three sessions, two to four weeks apart, with the best results four to six weeks after the final session. Maintenance every six to twelve months sustains results.
Minimal. Small injection marks usually resolve within 24 to 48 hours and most people return to normal activities the same day. Avoid exercise, alcohol and direct sun for 24 hours.
Skin boosters mainly hydrate and stimulate collagen through hyaluronic acid. Polynucleotides work at a deeper biological level, activating cellular repair and fibroblast activity. The two can be combined for a comprehensive result.
Some people notice better hydration and skin quality within days. Deeper regenerative effects build across the course, peaking four to eight weeks after the final session.
Yes — they work well with skin boosters, anti-wrinkle injections and lip filler. Eye-specific formulations (Plinest Eye and Nucleofill Soft Eyes) are also available for the under-eye area.
Plinest suits skin repair, dullness and photo-ageing; Nucleofill suits more advanced ageing and elasticity loss; Vitaran suits multiple concerns and first-time clients wanting immediate hydration. Mahtab confirms the right choice at your consultation.
Start your skin regeneration journey.
DIYAH AESTHETICS · MARYLEBONE NW1 & RICHMOND TW10
Polynucleotide Treatments in Marylebone and Richmond
Three advanced polynucleotide treatments for deep skin regeneration, tissue repair and lasting rejuvenation. Delivered by a GDC registered practitioner with over 10 years of clinical experience.
Specialist Polynucleotide Treatments at Diyah Aesthetics
Polynucleotides are a class of injectable treatments derived from highly purified DNA strands. They work at a cellular level to stimulate your skin’s own regenerative processes: increasing fibroblast activity, boosting natural collagen and elastin production, improving tissue hydration and accelerating the repair of damaged cells. This is not about adding volume. It is about restoring the biological health of your skin.
At Diyah Aesthetics, Mahtab offers three leading polynucleotide treatments: Plinest, Nucleofill and Vitaran. Each has a distinct formulation and mechanism, making the right choice dependent on your individual skin assessment. During your free consultation, Mahtab will evaluate your skin and recommend the most appropriate approach.
Plinest
PDRN-based polynucleotide that stimulates tissue regeneration and collagen synthesis. Proven for skin repair, hydration and overall quality improvement.
Nucleofill
High-concentration polynucleotide gel delivering intense hydration and cellular regeneration. Restores elasticity and deeply revitalises compromised skin.
Vitaran
Polynucleotide and hyaluronic acid combination for simultaneous regeneration and volumetric hydration. Targets multiple concerns in a single treatment.
Plinest
Plinest uses PDRN (polydeoxyribonucleotide), a highly purified compound derived from salmon DNA that is extensively researched and clinically validated. PDRN activates the A2A adenosine receptor pathway, which directly stimulates tissue regeneration, triggers fibroblast proliferation and promotes the natural production of collagen and extracellular matrix proteins.
The result is a measurable improvement in skin quality, texture and hydration that builds progressively over a course of treatments. Plinest is particularly effective for clients with dull, tired or photo-aged skin seeking genuine cellular renewal rather than surface-level improvement.
Tissue Regeneration
PDRN activates the A2A receptor pathway to directly stimulate skin cell repair and renewal.
Collagen Production
Triggers fibroblast proliferation for a sustained increase in natural collagen and elastin synthesis.
Deep Hydration
Improves the skin’s capacity to retain moisture at a structural level for lasting suppleness.
Skin Quality
Measurably improves overall texture, tone and luminosity through genuine biological rejuvenation.
Nucleofill
Nucleofill is a high-concentration polynucleotide gel that delivers an intensive regenerative effect for clients with more significant skin concerns. Its higher polynucleotide density means a stronger stimulation of fibroblast activity and a more pronounced improvement in skin elasticity, firmness and overall vitality.
Nucleofill is particularly suited to clients experiencing more advanced signs of skin ageing: loss of firmness, deep dehydration, reduced elasticity and a general decline in skin vitality that lighter treatments have not fully addressed.
High Concentration
Greater polynucleotide density delivers stronger fibroblast stimulation and more pronounced regenerative results.
Elasticity Restoration
Targets loss of skin firmness and elasticity with intensive bio-regeneration at a cellular level.
Deep Revitalisation
Restores vitality to compromised or chronically dehydrated skin that other treatments have not resolved.
Progressive Results
Results build across a course of treatments, with cumulative improvement in texture, tone and resilience.
Vitaran
Vitaran combines polynucleotides with hyaluronic acid in a single formulation, creating a dual-action treatment that addresses both cellular regeneration and volumetric hydration simultaneously. The polynucleotide component triggers the skin’s own repair and collagen-building processes, while the hyaluronic acid provides immediate structural hydration and skin plumping.
Vitaran is an excellent choice for clients who want the regenerative benefits of polynucleotides alongside the visible, immediate improvement in skin texture and hydration that HA delivers. It is also a strong option for those new to polynucleotide treatments who want a comprehensive result from a single product.
Dual Action
Combines polynucleotide regeneration with HA hydration for simultaneous biological and structural improvement.
Immediate Results
The HA component delivers visible skin plumping and texture improvement from the first session.
Long-Term Repair
Polynucleotides continue stimulating collagen and tissue repair progressively after each treatment.
Versatile
Suitable for a range of concerns and skin types. An ideal starting point for polynucleotide treatment.
Which Polynucleotide Treatment Is Right for You?
A guide to the key differences. Mahtab will confirm the right choice at your free consultation.
| Treatment | Best For | Mechanism | Course |
|---|---|---|---|
| Plinest | Skin repair, dullness, photo-ageing, texture | PDRN activates A2A receptor, stimulates fibroblasts and collagen synthesis | 3 sessions, 2 to 4 weeks apart |
| Nucleofill | Advanced ageing, elasticity loss, deep dehydration | High-concentration PN gel, intense fibroblast stimulation and elasticity restoration | 3 sessions, 2 to 4 weeks apart |
| Vitaran | Multiple concerns, first-time PN clients, immediate results | PN and HA combination, dual regenerative and structural hydration action | 3 sessions, 2 to 4 weeks apart |
Not Sure Which Treatment Is Right for You?
Book a free 15-minute consultation. Mahtab will assess your skin and recommend the right polynucleotide treatment for your goals.
Book Free Consultation WhatsApp UsPolynucleotide Treatment Prices
Transparent pricing. No hidden costs, no pressure. All prices apply across Plinest, Nucleofill and Vitaran.
Why Choose Diyah Aesthetics
GDC Registered
Mahtab holds GDC registration, a level of clinical governance most aesthetics practitioners do not have. Your safety underpins every treatment decision.
Dental Anatomy Expertise
Ten years of clinical experience in dental medicine provides an exceptional understanding of facial anatomy, tissue layers and precise injection placement.
Three Leading Formulations
Access to Plinest, Nucleofill and Vitaran means the right polynucleotide is chosen for your skin and goals, not simply the most available option.
Bespoke Treatment Plans
Every plan is tailored to your skin assessment and timeline. No standard protocols or generic approaches.
What to Expect
Free Consultation
Mahtab assesses your skin, discusses your concerns and recommends the right polynucleotide formulation for your goals.
Preparation
Skin is cleansed and a topical numbing cream applied for comfort before treatment begins.
Treatment
Precise microinjections across the face and neck. Sessions take 20 to 30 minutes from start to finish.
Aftercare
Small injection points fade within 24 to 48 hours. You can return to your normal routine the same day.
Results
Some immediate improvement in hydration. Regenerative results build progressively over four to eight weeks.
What Our Clients Say
21 five star reviews on Google
“The level of work, attention to detail and effort Mahtab puts into her treatments has been incredible. Professional, knowledgeable and genuinely cares about getting results.”
Verified Google Review“I was nervous about injectables but Mahtab explained everything so clearly. My skin looks hydrated and refreshed with no downtime at all. One of the best treatments I have had.”
Verified Google Review“Mahtab made me feel completely at ease from the start. The results were better than I expected. Natural, glowing and zero downtime. I will absolutely be coming back.”
Verified Google ReviewPolynucleotide FAQs
Start Your Skin Regeneration Journey
Book your free 15-minute consultation at our Marylebone or Richmond clinic. Mahtab will assess your skin and recommend the right polynucleotide treatment for your goals.
Book Free Consultation